Publications

PEER-REVIEWED PUBLICATIONS

Adams, P.D., Parker, P.J. TPA inducible activation of MAP-kinase. FEBS Lett. 290:77-82, 1991.

Adams, P.D., Parker, P.J. Activation of MAP-kinase by a MAP-kinase-kinase. J. Biol. Chem. 267:13127 13130, 1992.

Qin, X-Q., Livingston, D.M., Kaelin, W.G. Jr., Adams, P.D. Deregulated E2F-1 expression leads to S phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 91:10918-10922, 1994.

Adams, P.D., Sellers, W.R., Sharma, S.K., Wu, A.D., Nalin, C.M., Kaelin, W.G. Jr. Identification of a Cyclin-Cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol. 16:6623-6633, 1996.

Soucek, T., Pusch, O., Hengstschlager-Ottnad, E., Adams, P.D., Hengstschlager, M. Deregulated expression of E2F1 induces cyclin A and E associated kinase activities independently from cell cycle position. Oncogene 14:2251-2257, 1997.

Kiley, S.C., Adams, P.D., Parker, P.J. Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants. Cell Growth Differ. 8:221-230, 1997.

Adams, P.D., Li, X., Sellers, W.R., Baker, K.B., Leng, X., Harper, J.W., Taya, Y., Kaelin, W.G. Jr. The retinoblastoma protein contains a C terminal motif that targets it for phosphorylation by cyclin/cdk complexes. Mol. Cell. Biol. 19:1068-1080, 1999.

Chen, Y-N. P., Sharma, S.K., Ramsey, T.M., Jiang, L., Martin, M.S., Baker, K., Adams, P.D., Bair, K.W., Kaelin, W.G., Jr. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc. Natl. Acad. Sci. USA 96:4325-4329, 1999.

Ma, T., Van Tine, B.A., Wei, Y., Garrett, M.D., Nelson, D., Adams, P.D., Wang, J., Qin, J., Chow, L.T., Harper, J.W. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14:2298-2313, 2000.

Miyake, S., Sellers, W.R., Safran, M., Li, X., Zhao, W., Grossman, S.R., Gan, J., DeCaprio, J.A., Adams, P.D., Kaelin, W.G. Jr. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol. Cell. Biol. 20:8889-8902, 2000.

Hall, C., Nelson, D.M., Ye, X., Baker, K., DeCaprio, J.A., Seeholzer, S., Lipinski, M., Adams, P.D. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin/cdk2 substrate whose expression blocks S-phase progression. Mol. Cell. Biol. 21:1854-1865, 2001.

Leng, X., Noble, M., Adams, P.D., Qin, J., Harper, J.W. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol. 22:2242-2254, 2002.

Khare, L., Astrinidis, A., Senapedis, W., Adams P.D., Henske E.P. Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells. J. Med. Genet. 39:676-680, 2002.

Nelson, D.M., Ye, X., Hall, C., Santos, S., Ma, T., Kao, G.D., Yen, T.J., Harper, J.W.. Adams, P.D. Coupling of DNA synthesis and histone synthesis in S-phase independent of cyclin/cdk2 activity. Mol. Cell. Biol. 22:7459-7472, 2002.

Ye, X., Franco, A.A., Santos, H., Nelson, D.M., Kaufman, P.D., Adams, P.D. Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Molecular Cell. 11:341-351, 2003.

Daganzo, S.M., Erzberger, J.P., Lam, W.M., Skordalakes, E., Zhang, R., Franco, A.A., Brill, S.J., Adams, P.D., Berger, J.M., Kaufman P.D. Structure and function of the conserved core of histone deposition protein Asf1. Curr. Biol. 13:2148-2158, 2003.

Zhang, R., Poustovoitov, M.V., Ye, X., Santos, H.A., Chen, W., Daganzo, S.M., Erzberger, J.P., Serebriiskii, I.G., Canutescu, A.A., Dunbrack, R.L., Pehrson, J.R., Berger, J.M., Kaufman, P.D., Adams, P.D. Formation of macroH2A-containing senescence associated heterochromatin foci (SAHF) and senescence driven by ASF1a and HIRA. Developmental Cell 8:19-30, 2005.

Nagamori, I., Yomgida, K., Adams, P.D., Sassone-Corsi, P., Nojima, H. Transcription Factors, cAMP-responsive Element Modulator (CREM) and Tisp40, Act in Concert in Postmeiotic Transcriptional Regulation. J Biol Chem. 281:15073-15081, 2006.

Tang, Y., Poustovoitov, M.V., Zhao, K., Garfinkel, M., Canutescu, A., Dunbrack, R., Adams, P.D.*, Marmorstein, R.* Structure of a human ASF1a/HIRA complex and insights into specificity of histone chaperone complex assembly. Nature Struct. Mol. Biol. 13:915-920, 2006. *Corresponding authors.

Zhang, R., Liu, S.T., Chen, W., Bonner, M., Pehrson, J., Yen, T.J., Adams, P.D. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol. Cell Biol. 27:949-962, 2007.

Zhang, R., Chen, W., Adams, P.D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 27:2343-2358, 2007.

Ye, X., Zerlanko, B., Zhang, R., Somiah, N., Lipinski, M., Salomoni, P., Adams, P.D. Definition of pRB- and p53-dependent and –independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 27:2452-2465, 2007.

Ye X., Zerlanko B., Kennedy, A., Banumathy, G., Zhang R., Adams P.D. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Molecular Cell. 27:183-196, 2007.

Poleshko, A., Palagin, I., Zhang, R., Boimel, P., Castagna, C., Adams, P.D., Skalka, A.M., Katz, R.A. Identification of Cellular Proteins That Maintain Retroviral Epigenetic Silencing: Evidence for an Antiviral Response. J. Virology. 82 : 2313-2323 2008.

Ambagala, A., Bosma, T., Ali, M., Poustovoitov, M., Gershon, M.D. Adams, P.D., Cohen, J.I., VZV Immediate-Early 63 Protein Interacts with Human Anti-Silencing Function 1 Protein and Alters its Ability to Bind Histones H3.1 and H3.3. J. Virology. 83:200-9, 2008

Banumathy, G., Somaiah, N., Zhang, R., Schultz, D., Andrake, M., Ceulemans, H., Adams, P.D. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol. Cell. Biol. 29:758-70, 2009

Poleshko A., Einarson M.B., Shalginskikh N., Zhang R, Adams P.D., Skalka A.M., Katz R.A. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. Oct 30, 2009.

Kennedy, A.L., McBryan, T., Enders, G.H., Johnson, F.B., Zhang, R., Adams, P.D. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. BMC Cell Division. Jun 22;5:16, 2010.

Kreiling, J.A., Tamamori-Adachi, M., Sexton, A.N., Jeyapalan, J.C., Munoz-Najar, U.,  Peterson, A.L., Jayameenakshi, M., Rogers, E.S., Pchelintsev, N.A., Adams, P.D., Sedivy, J.M. Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell. 10: 292-304. 2011

Kennedy, A.L., Morton, J.P., Jamieson, N.B., Manoharan, I., McBryan, T., Doyle, B., Oien, K.A., Enders, G.H., Zhang, R., Sansom, O.J., Adams, P.D. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell. 42: 36-49. 2011.

Rai, T.S., Puri, A., McBryan, T., Hoffman, J., Tang, Y., Pchelintsev, N., van Tuyn, J., Marmorstein, R., Schultz, D.C., Adams, P.D. Human CABIN1 is a functional member of the    human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol. Cell. Biol., 31:4107-18, 2011.

Ray‐Gallet, D., Woolfe, A., Vassias, I., Pellentz, C., Lacoste, N., Puri, A., Schultz, D.C., Pchelintsev, N.A., Adams, P.D., Jansen, L.E.T., Almouzni, G. A crosstalk between H3.3 and H3.1 in vivo and alternative modes for HIRA‐dependent H3.3 deposition. Mol. Cell., 44:928-41, 2011.

Tang, Y., Puri, A., Ricketts, M., Rai, T., Hoffmann, J., Hoi, E., Adams, P.D., Schultz, D., Marmorstein, R. Identification of an Ubinuclein 1 region required for stability of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry, 51:2366-77, 2012.

Moyes, L.H., McEwan, H., Radulescu, S., Pawlikowski, J., Lamm, C.G., Nixon, C., Sansom, O.J., Going, J. J., Fullarton, G. M., Adams, P.D. Activation of Wnt Signalling promotes development of dysplasia in Barrett’s Oesophagus. J. Pathology, In press.

REVIEWS AND BOOK CHAPTERS

Adams, P.D., Kaelin, W.G. Jr. Transcriptional control by E2F. Sem. Cancer Biol. 6:99-108, 1995.

Adams, P.D., Kaelin, W.G. Jr. The cellular effects of E2F overexpression. In: Transcriptional Control of Cell Growth by the E2F Gene Family (Farnham P.J., ed.). Curr. Top. Microbiol. Immunol. 208:79-93, 1996.

Adams, P.D., Lopez, P., Sellers, W.R., Kaelin, W.G., Jr. Fluorescence activated cell sorting of transfected cells. Meth. Enzymol. 283:59-72, 1997.

Adams, P.D., Kaelin, W.G., Jr. Negative control elements of the cell cycle in human tumours. Curr. Opin. Cell. Biol. 10:791-797, 1998.

Adams, P.D., Ohh, M. Cloning of associated proteins by co-immunoprecipitation. In: Molecular Cloning (Sambrook, J., Fritsch, E.F., Maniatis, T. eds.), 3rd Edition, Section 18.60-18.68. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001.

Adams, P.D. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim. Biophys. Acta 1471:M123-133, 2001.

Harper, J.W., Adams, P.D. Cyclin-Dependent Kinases. In: Chemical Reviews, Protein Phosphorylation and Dephosphorylation (Ahn, N. ed.). The American Chemical Society 101:2511-2526, 2001.

Adams P.D., Seeholzer S., Ohh, M. Identification of Associated Proteins by Coimmunoprecipitation. In: Protein-Protein Interactions (Golemis, E., ed.), pp. 59-74. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2002.

Ye, X., Adams, P.D. Coordination of S-phase events and genome stability. Cell Cycle 2:185-187, 2003.

Adams, P.D., Cairns, P. Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells. Cancer Biol. Ther. 2:557-558, 2003.

Ye, X., Poustovoitov, M., Santos, S., Nelson, D.M., Adams P.D. Biochemical analysis of the cell cycle and cell cycle checkpoints in transiently transfected cells after collection with magnetic beads. Methods Mol. Biol., 281:261-270, 2004.

Poustovoitov, M., Serebriiskii, I., Adams, P.D. A two-step two-hybrid system to identify functionally significant protein-protein interactions. In: Methods: Analysis and Manipulation of Intracellular Signaling Cascades (Golemis, E.A., Chernoff, J., eds.). pp. 371-380. Elsevier Press, San Diego, CA, 2004.

Adams, P.D. Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs. Methods Mol. Biol. 296:189-196, 2004.

Cairns, P., Adams, P.D. Clipped wings: Epigenetic inactivation of APC. Cancer Biol. Ther. 3:965-966, 2004.

Adams, P.D., Golemis, E.A., (eds). Protein-Protein Interactions: A Molecular Cloning Manual, 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2005.

Zhang, R., Adams, P.D. Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle 6:784-789, 2007.

Adams P.D. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene. Invited review. 397: 84-93, 2007.

Adams, P.D. Remodeling chromatin for senescence. Invited Commentary. Aging Cell 6: 425-427, 2007.

Zhang, R., Adams, P.D., Ye, X. Design and application of an shRNA-based gene replacement retrovirus. Methods Mol. Biol. In: Gene Function and Analysis. Ed. Michael F. Ochs. 408: 211-221, 2007.

Adams P.D. Regulation of senescence by chromatin structure and E2F transcription factors. Invited review in Control of Cellular Physiology by Transcription Factors E2F. pp123-152. Research signpost, Ed. Yoshida, K., 2008.

Sedivy, J.M., Banumathy, G. Adams, P.D. Aging by epigenetics – a consequence of chromatin damage? Experimental Cell Research. 314 : 1909-17, 2008

Adams, P.D. Regulation of oncogene-induced senescence by Wnt-signaling – a convergence on melanoma. Cell Technology. 27: 875-879, 2008. (Translated into Japanese).

Adams, P.D., Enders, G.H. Wnt signaling and senescence: a tug of war in early neoplasia? Cancer Biology and Therapy. 7: 1706 – 1711, 2008.

Adams, P.D. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Molecular Cell. 36: 1-14, 2009.

Banumathy, G. Adams, P.D. Chromatin in senescent cells: a conduit for the anti-aging effects of Wnt signaling? In: Epigenetics of aging. Springer Press. Tollefsbol, T.O. (Ed). pp77-106, 2010

Banumathy, G. Adams, P.D. The secretome of senescent cells. In: Cellular senescence and tumor suppression. Springer Press. Adams, P.D., Sedivy, J.S. (Eds).  pp109-124, 2010

Adams, P.D., Sedivy, J.S. (Eds). Cellular senescence and tumor suppression. Springer Press. 2010

Adams, P.D. The senescence secretome and its impact on tumor suppression and cancer.  In: Cell cycle deregulation in cancer. Springer Press. Enders, G (Ed).  pp139-156, 2010

Cruickshanks, H. A and Adams, P.D. Chromatin: a molecular interface between aging and cancer. Curr. Op. Gen. Dev. 21: 100-6. 2011

Ivanov, A., Adams, P.D. A damage limitation exercise. Nat. Cell. Biol. 13: 193-5. 2011

Rai, TS., and Adams, P.D. Lessons from senescence: chromatin maintenance in non-proliferating cells. Biochimica et Biophysica Acta. Aug 3, 2011.

Kennedy, A.L., Adams, P.D., Morton, J.P. Ras, PI3K/Akt and senescence: paradoxes provide clues for pancreatic cancer therapy. Small GTPases. 2: 264-267, 2011.

van Tuyn, J.,  Adams, P.D. Signaling the end of the line. Nat. Cell. Biol., 14:339-41, 2012.

(See above for peer-reviewed publications)